A group of researchers compared conventional and digital additive manufacturing of hard occlusal stabilization splints (SS) using technical and clinical parameters and 14 subjects underwent sequence of tests and questionnaires for 12 weeks. On a scaled of great discomfort,  Conventional had a score of 42 while Additive Manufacturing performed 15, meaning 3D Printed Stabilization Splints are far more comfortable and preferred over the conventional ones.

Source: https://www.tandfonline.com/doi/abs/10.1080/23337931.2018.1497491