A Team of researchers from Boston and India used 3D Printing to enhance the Applicators used in PDT for Oral Cancer Treatment. PDT or Photodynamic Therapy is a light based spatially-targeted cytotoxic therapy that targets cancer cells. They developed an Intraoral Light Delivery System consisting of modular 3D Printed Light Applicators with pre-calibrated dosimetry and mouth props that can be utilized to perform PDT in conscious subjects without the need of extensive infrastructure or manual positioning of an optical fiber. The Applicators were tested on five subjects with T1N0M0 oral lesions where no residual cancer cells were noted after the treatment. The team used Autodesk Fusion 360 to design the light applicators, and they were printed on a Stratasys Objet Pro system out of VeroBlue and VeroBlack filament.